TomRenz
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Cancer: An Unbiased Overview In Preparation for Our Upcoming War On Cancer
April 01, 2024

If you’ve been following this Substack, or paying attention to the headlines you’ve probably read about ‘turbo cancer’, cancer vaccines and Biden’s operation Cancer Moonshot. For those that don’t already know, my wife has cancer - and in light of these factors - I felt it was necessary to examine the subject closer. Surely, we all know someone who has been affected by the dreaded “C" word but how many really understand what that diagnosis means?

For the sake of brevity, I’m not going to delve too deep into the nuance of this subject as it truly is expansive in scope. Consider this an introduction on the subject of cancer and stay with me as we examine factors that may influence or contribute to cancer and what happens after diagnosis. Also, as a disclaimer, I am looking at all aspects of cancer - including mainstream. I am going to do what I always do, which is to follow the evidence. I do not care where it goes (though I’ve done enough to have a good idea), my job is to simply follow the evidence and share the truth.

According to the Mayo Clinic, cancer is the second leading cause of death in the world. In February 2024, The World Health Organization (WHO)’s cancer agency, the International Agency for Research on Cancer (IARC) revealed that “in 2022, there were an estimated 20 million new cancer cases and 9.7 million deaths. The estimated number of people who were alive within 5 years following a cancer diagnosis was 53.5 million. About 1 in 5 people develop cancer in their lifetime, approximately 1 in 9 men and 1 in 12 women die from the disease.” Cancer rates are skyrocketing, and they expect to see that upward trend continue over the next two and a half decades. In fact, they predict more than 33 million new cases - a 77% increase by the year 2050!

The Center for Disease Control (CDC) defines cancer as “diseases in which abnormal cells divide out of control and are able to invade other tissues. Cancer cells can spread to other parts of the body through the blood and lymph systems, which help the body get rid of toxins”. Cancer.gov tells us that cancer is “a genetic disease caused by changes to genes [pieces of DNA] that control the way our cells function, especially how they grow and divide.”Share

Dr. Robert Peter Gale, MD, PhD, DSC(hc), details this further on Merck Manuals Consumer Version website:

“A cancer is an abnormal growth of cells (usually derived from a single abnormal cell). The cells have lost normal control mechanisms and thus are able to multiply continuously, invade nearby tissues, migrate to distant parts of the body, and promote the growth of new blood vessels from which the cells derive nutrients. Cancerous (malignant) cells can develop from any tissue within the body.

As cancerous cells grow and multiply, they form a mass of cancerous tissue—called a tumor—that invades and destroys normal adjacent tissues. The term tumor refers to an abnormal growth or mass. Tumors can be cancerous or noncancerous. Cancerous cells from the primary (initial) site can spread throughout the body (metastasize).”

Simply put, the body is made up of trillions of cells and cancer can start in any of these cells. Normally, human cells grow through a process called cell division. Cells that grow old or damaged die and new cells take their place. If this process breaks down, and abnormal or damaged cells grow and multiply when they shouldn’t - that is when cells may form tumors - which are lumps of tissue. Tumors can be cancerous or not cancerous (benign). 

Cancerous tumors can invade nearby tissues and via the lymphatic system - travel to other places in the body to form new tumors (metastasis). Cancerous tumors may also be called malignant tumors. Cancers of the blood, like leukemias generally don’t cause solid tumors to form. Benign tumors do not spread into, or invade, nearby tissues and unlike cancerous tumors they do not usually grow back when removed.

One of the more interesting lines of thought related to origins of cancer relates to oxygen and metabolism in cancer. It appears to me that this has stood the test of time despite the fact that much of the current research centers on genetic changes. Obviously cancer cells are genetically different but the hypoxia theory seems to have stood the test of time and may well account for the changes that occur that result in cancer (though fast forwarding to the present day I think we need to consider the impact of the gene therapy jabs and other potential gene altering garbage we are putting in our bodies).

In 1931 Dr. Otto Heinrich Warburg won a Nobel Prize by showing that a root cause of cancer is low cellular oxygenation levels (hypoxia). In “The Metabolism of Tumours” Warburg demonstrated that all forms of cancer are characterized by two basic conditions: hypoxia & acidosis. “Acidosis is caused by an overproduction of acid that builds up in the blood or an excessive loss of bicarbonate from the blood (metabolic acidosis) or by a buildup of carbon dioxide in the blood that results from poor lung function or depressed breathing.” The data reveals that oxygen deficiency creates an acidic state within the body and that ‘cancer cells are anaerobic (do not breathe oxygen) and cannot survive in the presence of high levels of oxygen, as found in an alkaline state’.

"All normal cells have an absolute requirement for oxygen, but cancer cells can live without oxygen - a rule without exception. "Deprive a cell 35% of its oxygen for 48 hours and it may become cancerous.”

On February 24, 1956, Warburg published “On the Origins of Cancer Cells” in which he summarized that “the cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.” He explains that normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs - in great part - by fermentation.

So, what does it all mean? In basic terms it means cancerous cells can live without oxygen whereas healthy cells cannot. Depriving a cell of oxygen kills off the good cells and leaves (or creates) the bad - which get their energy needs by fermentation of sugar instead of oxygen. A 2015 NIH Study entitled “The Role of Hypoxia in Cancer Progression, Angiogenesis, Metastasis, and Resistance to Therapy” reveals data that indicates there is a correlation between the severity of the tumor, it’s responsiveness to treatment and the duration of hypoxic conditions in which it developed. Meaning, the longer the cell went without proper cell oxygenation - the more solid the tumor is likely to be. “Longer exposure to hypoxia is associated with high frequency of DNA breaks, accumulation of DNA replication errors since hypoxia hampers DNA repair systems including homologous recombination and mismatch repair, potentially leading to genetic instability and mutagenesis.” The more solid the tumor, the more resistant it’s likely to be when up against mainstream treatments like chemo or radiation.

“Hypoxia is one of the main features of solid tumors and was shown to correlate with poor prognosis of cancer patients.

While hypoxia is lethal for many cells, a subpopulation of tumor cells is able to not only adapt to hypoxic conditions but also become resistant to chemo- and radiotherapy. The role of hypoxia in the phenomenon of therapy resistance has been acknowledged for at least 60 years.”

The complex process by which cancerous cells develop from healthy cells is known as Malignant transformation. There are several steps necessary including: initiation, promotion, and spread.

Dr. Gale provides an overview of the development and spread of cancer, and he breaks down the above-mentioned processes for us.

Initiation

“The first step in cancer development is initiation, in which a change in a cell’s genetic material (a mutation) primes the cell to become cancerous. The change in the cell’s genetic material may occur spontaneously as a random event or due to a gene mutation or be brought on by an external exposure to a substance that causes cancer (a carcinogen).

Carcinogens include many chemicals, tobacco, viruses, radiation, and sunlight. However, not all cells are equally susceptible to carcinogens. And not all people exposed to a carcinogen will develop cancer. The risk depends on many factors, for example, the amount of exposure the person had to that carcinogen or whether the person has a genetic predisposition to a certain type of cancer.

Promotion

The second and final step in the development of cancer is promotion. Agents that cause promotion, or promoters, may be substances in the environment or even some medications, such as sex hormones (for example, testosterone taken to improve sex drive and energy in older men). Unlike carcinogens, promoters do not cause cancer by themselves. Instead, promoters allow a cell that has undergone initiation to become cancerous. Promotion has no effect on cells that have not undergone initiation.

Some carcinogens are sufficiently powerful to be able to cause cancer without the need for promotion. For example, ionizing radiation (which is used in x-rays and is produced in nuclear power plants and atomic bomb explosions) can cause various cancers, particularly sarcomas, leukemia, thyroid cancer, and breast cancer.

Spread

Cancer can grow directly into (invade) surrounding tissue or spread to tissues or organs, nearby or distant. Cancer can spread through the lymphatic system. This type of spread is typical of carcinomas. For example, breast cancer usually spreads first to the nearby lymph nodes in the armpit, and only later does it spread to distant sites. Cancer can also spread via the bloodstream. This type of spread is typical of sarcomas.”

Cancer.gov lists differences between cancer cells and normal cells, and they differ in many ways. For example, cancer cells:

  • Grow in the absence of signals telling them to grow. Normal cells only grow when they receive such signals. 

  • Ignore signals that normally tell cells to stop dividing or to die (a process known as programmed cell death, or apoptosis).

  • Invade into nearby areas and spread to other areas of the body. Normal cells stop growing when they encounter other cells, and most normal cells do not move around the body. 

  • Tell blood vessels to grow toward tumors.  These blood vessels supply tumors with oxygen and nutrients and remove waste products from tumors.

  • Hide from the immune system. The immune system normally eliminates damaged or abnormal cells. 

  • Trick the immune system into helping cancer cells stay alive and grow. For instance, some cancer cells convince immune cells to protect the tumor instead of attacking it.

  • Accumulate multiple changes in their chromosomes, such as duplications and deletions of chromosome parts. Some cancer cells have double the normal number of chromosomes.

  • Rely on different kinds of nutrients than normal cells. In addition, some cancer cells make energy from nutrients in a different way than most normal cells. This lets cancer cells grow more quickly. 

    Share

Dr. Gale writes, ‘cancerous tissues (malignancies) can be divided into those of the blood and blood-forming tissues (leukemias and lymphomas) and “solid” tumors (a solid mass of cells)”.

“Leukemias and lymphomas are cancers of the blood and blood-forming tissues and cells of the immune systemLeukemias arise from blood-forming cells and crowd out the production of normal blood cells in the bone marrow. Cancer cells from lymphomas expand lymph nodes, producing large masses in the armpit, groin, abdomen, or chest.

Carcinomas are cancers of cells that line the skin, lungs, digestive tract, and internal organs. Examples of carcinomas are cancer of the skin, lungs, colon, stomach, breasts, prostate, and thyroid gland. Typically, carcinomas occur more often in older than in younger people.

Sarcomas are cancers of mesodermal cells. Mesodermal cells normally form muscles, blood vessels, bone, and connective tissue. Examples of sarcomas are leiomyosarcoma (cancer of smooth muscle that is found in the wall).”

If you’re wondering why I haven’t mentioned Melanoma or some other classification of cancer you may have heard of - it’s because this Substack is not meant to be an exhaustive presentation of the various types of cancers, tumors, tests and treatments. There are more than 100 different types of cancer, and the data is quite extensive. Most cancers are named for the organ or type of cell in which they start.

The WHO reports that the three major cancer types in 2022 were lungbreast and colorectal cancersColorectal cancer is on the rise - especially among young adults. Diagnostic criteria vary for the type and location of the cancer or tumor. Imaging tests (like MRI’s and CT’s), biopsies, and tumor markers all aide in staging the disease and determining treatment options.

The Merck Manual states that “treatment plans take into consideration the type of cancer, including its location, its stage (how large and widespread the cancer is), and its genetic characteristics, as well as specific characteristics of the person being treated."

Most mainstream and widely accepted cancer treatment plans include surgeryradiation therapychemotherapy or a combination of one or more of those. Other plans involve biological therapy or stem cell transplants, also commonly known as bone marrow transplants. Chemotherapy is not the only systemic cancer therapy available - hormone therapy, immune therapy, gene therapy and other targeted drug therapies can be utilized. For example, this is what the Food & Drug Administration (FDA) has to say about gene therapy as an approved treatment for cancer.

 

Unless you have never heard of me or any of my work you know I’m more than a little suspect of gene therapy. In regards to cancer I remain more than a little skeptical and will be discussing details of why coming up. That said, the most foundational concern I have is that our regulators are corrupt and so is big pharma so the idea of allowing someone I find inherently untrustworthy tinker with my genes seems absurd. I also believe there are many unexplored, lower risk treatments that need proper study before we start altering the genetic makeup of a person.

New treatments are being developed and tested all the time and the same thing can be said for radiation therapy. There are many types of radiation therapy both internal and external. The most common type is external beam radiation, and even that is not so simple. Merck lists several types of external beam radiation:

It’s notable that radiation both causes and treats cancer. It is not uncommon for the radiation done while attempting to detect, diagnose or treat cancer - actually end up causing secondary cancer.

Alternative treatments like oxygen therapyacupuncture and eliminating sugar from one’s diet have their place. Some experts will tell you that cancer can be caused by parasites - so anti parasitic medications like Ivermectin and Benzimidazoles (de worming medications) such as Fenbendazole are being explored with promising results (especially for colorectal and pancreatic cancer). Oncologists and cancer researchers like Dr. William Makis report that “Fenbendazole has at least 12 proven anti-cancer mechanisms in vitro and in vivo”. You may have heard of the Joe Tippens Protocol which combines anti-parasitic medications with other supplements and CBD and other alternative treatment methods.

I believe many of these “alternative treatments” are potentially very valuable. Unfortunately we have corruption issues here as well. There is little or no funding for the proper study of many of these alternative treatments in cancer. The signals and case studies look very promising but the cost to truly understand when, where and how to use these treatments makes clinical studies impossible to undertake. This MUST change.

There are times and places for many treatments and the only reason we are not studying them properly is that big pharma cannot charge $120k for a B17, Ivermectin, or FenBen treatment (that’s how much my wife’s first treatment cost) so they won’t fund it and the corrupt officials that control the study money (like Fauci in his previous position) won’t issue federal grants because their big pharma masters would lose money. Without the proper studies the use of alternative treatments includes a lot more guesswork than is necessary and so the question for cancer patients is whether they want to risk their life with big pharma or risk their life with alternative treatments that may be effective but that we do not have all the data on. There are numerous alternative treatments that are part of mainstream medicine in other countries and we won’t even look at them here because of the corruption and collusion between HHS and big pharma. It is infuriating and incredibly sad to think of the number of lives lost because we won’t properly study treatments that have been demonstrated to have a major impact on cancer.

Subscribing to our newsletter allows us to continue our work. Please support us so we can continue to fight for truth.

To be very clear, I am not a doctor, nor am I advocating for - or against - any treatment listed within this Substack. I’m merely sharing a collaboration of information as it’s presented by the experts. That said, I will be advocating for a number of treatments and studies coming up. I am learning EVERYTHING I can about cancer and intend to fight this fight. We have plans but I don’t want to telegraph all my punches so stay tuned.

Sources:

  1. Cancer - Symptoms and causes - Mayo Clinic

  2. United States Cancer Statistics | Cancer | CDC

  3. https://www.who.int/news/item/01-02-2024-global-cancer-burden-growing--amidst-mounting-need-for-services

  4. Development and Spread of Cancer - Cancer - Merck Manuals Consumer Version

  5. the_root_cause_of_cancer_dr_otto_warburg.pdf (cancer-cell-treatment.com)

  6. Otto Warburg | Kill Cancer Cells

  7. On the Origin of Cancer Cells | Science

  8. The Prime Cause of Cancer - Otto Warburg, Trung Nguyen - Google Books

  9. What Is Cancer? - NCI

  10. https://www.cancer.org/cancer/risk-prevention/infections/infections-that-can-lead-to-cancer/parasites.html

  11. Joe Tippins' Fenbendazole Protocol For Cancer (deeprootsathome.com)

  12. Radiation induced secondary malignancies: a review article - PMC (nih.gov)

  13. How Gene Therapy Can Cure or Treat Diseases | FDA

  14. Abstract 2313: Fenbendazole induces cell cycle arrest in colorectal cancer cells and patient-derived colon cancer organoids | Cancer Research | American Association for Cancer Research (aacrjournals.org)

  15. https://vigilantnews.com/post/ivermectin-could-be-a-powerful-drug-for-fighting-cancer-heres-why/

  16. The Overlooked Miracle Drug for Cancer? Why Big Pharma Fears Fenbendazole – Vigilant News Network

  17. Parasites that Can Lead to Cancer | American Cancer Society | American Cancer Society

  18. Cancer Moonshot | The White House

  19. Johns Hopkins Study: Anti-Parasitic Drug Slows Pancreatic Cancer in Mice | Johns Hopkins Medicine

  20. cancer-treatment-and-survivorship-facts-and-figures-2019-2021.pdf

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We MUST Pass HB73 To Counter Disease X & the WHO Treaty
The Abortion Argument is an Outright Lie

Please Support us @ www.TomRenz.com and tomrenz.substack.com.

On Wednesday of last week I testified in the Ohio Senate in favor a piece of legislation that will be critical to stopping the WHO treaty and Disease X - Ohio HB73 (you can see my full testimony here:

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). HB73 was passed through the Ohio House with a huge majority and bipartisan support. The bill prevents hospitals and pharmacists from witholding life-saving medications - as they did during COVID - by requiring that they allow patients access to medications prescribed by their doctors. Now, despite the MASSIVE support for this common sense legislation, it appears that Ohio REPUBLICAN Steve Huffman is lying and pushing this bill as somehow expanding abortion rights.

Let me begin by explaining why this legislation is so critical. During COVID our corrupt federal government incentivized hospitals killing COVID patients. Yes, I said it and - as an attorney - I mean it. When a person went to a hospital during the height of COVID the hospitals received extra money for diagnosing the person with COVID (this is why there were literally zero flu diagnoses for a substantial period of time in the entire country). Once a person was diagnosed with COVID the hospital then received additional money from treating with Remdesivir, more again when the patient was put on assisted breathing, more yet when they were ventilated, and a final big old bonus when the patient died. Instead of offering hospitals more money for patients recovering the “experts” from Washington paid more for dead patients. Then to top this whole murder for hire scheme off, the cesspool that is DC extended legal immunity to these same hospitals from any malpractice, wrongful death, etc. that occurred from “COVID treatments.”

As a result, hospitals blocked patients from access to treatments like Ivermectin and HCQ. While some may attempt to argue that these treatments were unproven it is absolutely inarguable that withholding treatments like Budesonide (at proper dosages and for proper durations) were absolutely useful for pneumonia regardless of the cause of the pneumonia. Further, even if it was unclear whether or not HCQ or Ivermectin were useful (they were), why is it the government or hospital’s business to interfere with a patient receiving a properly prescribed medication that no one could argue would be dangerous in any way? Why wouldn’t pharmacists fill prescriptions for a Nobel prize winning drug that was known to be safe around the world for decades? There were zero valid reasons - it was simply corruption based on the fact that people getting well meant less bonus money from Fauci’s corrupt scheme.

HB73 would stop this and require prescriptions be filled and the patient be able to receive the drugs. This would allow doctors to, with informed consent, innovate if/when the next plandemic hits. The WHO and everyone else has already stated that Disease X is on the way (probably from the gain-of-function work being carried out on American soil now in our many university tied labs still being funded by our corrupt Biden controlled HHS). The innovation would demonstrate effective treatments in Ohio and that would spread all over. This bill actually has the potential to expose another cover up of a similar murder for hire scheme when the next plandemic hits because people would see Ohioans getting better while patients in a WHO or Federally sponsored death scheme keep dying.

So this bill passed the Ohio GOP controlled House with massive bipartisan and grassroots support. Yet in the Senate it appears to have been held up for a long time in committee and now the Republican in charge of that committee has been accused of lying about that bill despite literally hearing testimony from me and others a few days ago demonstrating what he is saying is clearly wrong. Look at this post from OAMF - an Ohio medical freedom group I work with extensively:

Find this tweet at https://x.com/ohioamf/status/1794091547660570927?s=61&t=chcz9dPKlqWymEZk8PFPug.

It appears that the lobbyists for big pharma, the hospitals, and pharmacies are looking for a reason to oppose this bill so they can keep the murder for money gravy train moving. It also appears that certain elected officials and lobby groups are more interested in big money than what Ohioans want or need to stay safe. In a completely dishonest attempt to provide cover for Republicans that are willing to sell out to big money, despite massive GOP grassroots support, these folks are attempting to claim this bill will somehow expand abortion. It won’t in any way. If, in fact, Huffman is working with crooked lobbyists to push this narrative then he - and they - are simply lying about the bill.

My stance on abortion is very clear and well-known; I am 100% right to life. I will never support a pro-abortion bill in any way but I support this bill completely. With that said, let me explain to you why this bill will do NOTHING to expand abortion.

In 2023 Ohio sadly passed Issue 1. Issue 1 is was a Constitutional Amendment that became Article 1 Section 22 of the Ohio Constitution. The entirety of that Amendment is here:

As you can see this Amendment plainly states in Section B that “The State shall not, directly or indirectly, burden, penalize, prohibit, interfere with, or discriminate against either: 1. An individual’s voluntary exercise of this right or 2. A person or entity that assists an individual in exercising this right…” regarding abortion (continuing one’s own pregnancy). This means that no law in Ohio can be passed that will, in ANY way limit access to abortion or abortion meds without Amending the Constitution further (I would be happy to volunteer my time to assist in that amendment process but it is irrelevant to this bill).

People in Ohio - by the Constitution have the broadest possible access to abortion drugs already and this bill is a statute - NOT a Constitutional Amendment - so it can neither expand or limit the rights laid out in the Constitution. Huffman and the lobbyists know this and I testified to it directly (you can see my full testimony here: 

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). There is NO legitimate or good faith argument that this bill will expand access to abortion in any way that does not already exist and anyone telling you otherwise is simply a liar.

This law is one of the most carefully crafted state bills I’ve seen in the country. It provides proper liability protection for doctors, hospitals, and pharmacists while also allowing the right people to be held accountable if they are wreckless in providing treatment. At the same time the bill will allow doctors and patients, with informed consent, to decide what is best for their specific situation instead of corrupt bureaucrats. The real question our politicians need to ask themselves is whether they want the WHO and people like Fauci to decide what’s best for people or their doctors - a question that is especially meaningful for people without the economic means to fight back. Equally importantly to ask is whether a handful of complete RINOs will be able to undermine the credibility of a strong Ohio Republican Party. I guess we will see.

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Trump 2024 - A Snake in the Grass?
The Tom Renz Show ep. 390

If we have another Biden presidency our nation is done. The globalists at the WEF and the enemies of America are using this corrupt POS to infiltrate and destroy our nation. Donald Trump is our best bet moving forward but there are a LOT of people very interested in infiltrating his inner circle and undermining what he's trying to do. To that extent we have some serious questions about Trump's main gatekeeper and the head of his PAC. This person is ideally positioned to cause trouble and is working directly with Pfizer, Gilead, and GAVI. MAGA needs to support the real president by helping watch for infiltrators. 

Rumble: 

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My Twitter/X posts on Susie Wiles:

BREAKING: Top Trump Advisor is Working for Consulting Company That Also Supports Democrats and is Owned by a Company Tied to WEF: I absolutely support Donald Trump for President but there is a snake in the woodshed. Unless @realDonaldTrump is surrounded by advisors that are selling out I cannot explain his support for Johnson and other RINOs. @SpeakerJohnson is a sellout and Trump’s continued support for #RINOs that will absolutely throw him under the bus is beyond my comprehension. Of course when his top advisors are partners in companies that represent Pfizer, Gilead & GAVI in a company owned by the #WEF I can see why he’d be getting bad advice. Maybe people like Suzy should not be advising the President on what the #Trump2024 crowd wants… just saying but mRNA fans usually are sellouts. We the People MUST help Trump watch for sellouts… maybe I’m wrong but this deserves investigation. More in the comments but I’m tired of the support for people stabbing America in the back.

Link: https://x.com/RenzTom/status/1782225573193855215

Susie Wiles (the #Trump2024 campaign manager, pac leader, gatekeeper to @realDonaldTrump & partner in Mercury LLC - a company representing Democrats Pfizer Gilead GAVI the UN Foundation & tied to the WEF) is apparently NOT the only person we need to be investigating around Trump. If #WeThePeople of MAGA want to win we need to help Trump drain the swamp around him. This is critical and systemic. Thank you Alex Jones for helping me get this out & keep an eye on @drdrew this evening for more.

Link: https://x.com/RenzTom/status/1783120183755747432

https://x.com/MailOnline/status/1783097752030740968

https://nationalfile.com/susie-wiles-who-oversees-trumps-endorsements-is-co-chair-of-firm-managed-by-recent-pfizer-vice-president/

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Cancer as Metabolic Disease

Thank you for joining me again as I continue to examine, without bias - the different theories on the origins, development and treatment of cancer. If you missed my previous Substacks in this cancer series, please feel free to check those out here and here.

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An increasingly popular, although admittedly not mainstream theory - is that cancer is a metabolic disease. This article is not intended to be a comprehensive presentation of the theory but intended to serve as a basic overview to introduce you to the subject. Much like the theory that some cancers are parasitic in nature, the idea that cancer is a metabolic disease - is not widely examined or acknowledged by the mainstream medical system. Outspoken advocates in support of the theory assert that this approach is not being recognized as an effective alternative to the radiation and chemotherapies that are currently being utilized - because there is little money to be made.

Chemotherapy and radiation bring in billions of dollars in revenue and some experts believe that the financial incentives to continue to recommend these treatments keep the scale tipped in their favor despite the fact that they are extremely toxic. One is a money generating approach, the other is not - so why would they engage in research that could potentially cut into (or decimate) the profits of a multibillion-dollar industry? Further, while chemo and radiation can be very effective, the side effects can cause a number of other issues including an increased likelihood of recurrence of cancer. Cancer does kill and chemo/radiation do frequently work well to stop it but what if there is another way that had fewer side effects? Drugs or supplements that could cure cancer without the need for other drugs to combat their side effects? It is certainly unseemly to discuss but it is inarguable that it would be a financial disaster for those making money from cancer if something like that were to become available.

Many physicians and oncologists are completely unfamiliar with the concept of cancer as a complex metabolic disease. It’s simply not taught, or it’s just dismissed outright. Most cancer research today is focused on gene mutations and the concept of “personalized medicine” in cancer involves the development of drugs and things like mRNA gene therapies. These gene therapies and drugs are being developed - presumably -to target specific mutations that are found in various tumors - with the hope of correcting the disease.

Some experts, like Dr. Thomas Seyfried will tell you that the problem with that is that there are thousands, possibly millions of mutations in tumor cells which makes targeting them a daunting task that comes with toxic adverse effects. Dr. Seyfried received his Ph.D. in Genetics and Biochemistry from the University of Illinois and boasts impressive credentials. He published Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer and in his book, Dr. Seyfried presents an alternative origin of cancer based on the theories of Dr. Otto Warburg, who found that the root cause of cancer is a combination of low cellular oxygenation (hypoxia) and acidosis. In his “On the Origins of Cancer Cells” publication Warburg summarized that “the cause of cancer is the replacement of the respiration of oxygen in normal body cells by a fermentation of sugar.” Normal body cells meet their energy needs by respiration of oxygen, whereas cancer cells meet their energy needs - in great part - by fermentation.

Warburg showed that cancer cells are fermenters of glucose. Dr. Seyfried expands on that theory and asserts that cancer is a disease of cellular metabolic dysfunction due to damaged mitochondria.

 

He claims that glucose is metabolized to the point of pyruvate which is then fermented. Almost all cancer cells have this property because tumor cells must ferment either glucose (or amnio acids like glutamine) for survival and growth since they are anaerobic and cannot survive without oxygen.

Dr. Seyfried concludes that cancer is not a genetic disease and that the mutations are merely ‘downstream epiphenomenon of damaged respiration’. Simply put, he asserts that the genetic mutations are red herrings caused by mitochondria that have suffered some sort of insufficiency or damage. If the mitochondria are healthy - you will not get cancer. Different chemicals, radiation, toxins, inflammation, hypoxia, viruses and inherited genes can damage functionality of mitochondria.

Cell Death & Disease published Hypoxia Regulates the Mitochondrial Activity of Hepatocellular Carcinoma Cells through HIF/HEY1/PINK1 Pathway’ and revealed the following:

“Hypoxia is commonly found in cancers. Hypoxia, due to the lack of oxygen (O2) as the electron recipient, causes inefficient electron transfer through the electron transport chain at the mitochondria leading to accumulation of reactive oxygen species (ROS) which could create irreversible cellular damages.”

A 2023 review ‘Hypoxic Microenvironment in Cancer: Molecular Mechanisms and Therapeutic Interventions tells us that ‘hypoxia damages the cellular genome and drives carcinogenesis’.

“Hypoxia plays a central role in cancer progression and resistance to therapy by promoting various changes in the biology of stromal cells in the TME, including immune cells.”

Ask yourself, how much does genetic manipulation (gene therapy) affect the functionality of mitochondria? What is the effect of inserting experimental mRNA (modRNA) into the genes of the recipients and their offspring?

The metabolic theory of cancer claims glucose, oxidative stress, and mitochondrial health affect the onset and spread of the disease. In addition to pointing to new directions of research, Dr. Seyfried elaborates on a non-toxic mode of treatment, therapeutic fasting and a ketogenic diet. The ketogenic diet is a low carb/high fat diet and was originally used as one of the first treatments of epilepsy in children. The ketogenic diet (KD) capitalizes on the inability of the damaged cancer cell mitochondria to metabolize ketones, thus starving them while maintaining healthy cells.

Because cancer cells develop quickly on glucose and glutamine, it has been demonstrated that a ketogenic diet can effectively deprive malignant cells of glucose. Ketogenic diets have a fairly straightforward concept. In the simplest way I can explain it - if glucose serves as the main fuel for cancer, then reducing your consumption of carbohydrates and substituting them with other fuels, like fats, will force your body to enter a state of ketosis. Tumors that are fueled by glucose will have difficulty trying to compete with normal cells for the restricted source of glucose. Tumor cells can’t utilize the ketones for energy like the normal, healthy cells can. The body should be restricted from the primary fuels for the tumor while the body transitions to the ketones to fuel the body. Simply put, if you starve the malignant cells of its fuel, the theory is that it will kill tumor cells.

 

A paper published by Seyfried et al in BMC Press-pulse: A Novel Therapeutic Strategy for the Metabolic Management of Cancer’ concluded the following:

“Hyperbaric oxygen therapy combined with the calorie restricted ketogenic diet will kill tumor cells through apoptotic and anti-angiogenic mechanisms while also reducing inflammation in the tumor microenvironment and systemically.”

A 2021 NIH publication called ‘Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities’ documented the following:

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“The ketogenic diet (KD), a high-fat and very-low-carbohydrate with adequate amounts of protein, has shown antitumor effects by reducing energy supplies to cells. This low energy supply inhibits tumor growth, explaining the ketogenic diet’s therapeutic mechanisms in cancer treatment.”

A 2015 NIH study entitled ‘Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy’ published some interesting findings.

“Mice receiving the combination therapy demonstrated a marked reduction in tumor growth rate and metastatic spread and lived twice as long as control animals. To further understand the effects of these metabolic therapies, we characterized the effects of high glucose (control), low glucose (LG), ketone supplementation (βHB), hyperbaric oxygen (HBOT), or combination therapy (LG+βHB+HBOT) on VM-M3 cells. Individually and combined, these metabolic therapies significantly decreased VM-M3 cell proliferation and viability. HBOT, alone or in combination with LG and βHB, increased ROS production in VM-M3 cells. This study strongly supports further investigation into this metabolic therapy as a potential non-toxic treatment for late-stage metastatic cancers.”

Drugs like Gleevec and Herceptin target the same metabolic pathway that the ketogenic diet does. The difference is - a ketogenic diet theoretically targets all cancers whereas the drug specific ones - target those pathways only in the individuals with that mutation. Some experts are asking - why use toxic drugs when there is another alternative to do the same thing without toxicity to the body? Why are we attempting to genetically modify people before we attempt something as simple as a ketogenic diet? Please note - these are the experts theories - I’ll get to my thoughts in a moment.

A 2021 NIH paper ‘Ketogenic Diet for Cancer: Critical Assessment and Research Recommendations’ summarizes the strength of evidence of beneficial effects of KD for cancer related outcomes in pre-clinical and clinical studies.

The paper lists the following research recommendations for clinical studies examining the effects of KD on cancer development and progression:

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  • Conduct small, rigorous non-randomized trials with homogeneous patient groups and common cancer sites to assess whether KD produces a “signal” on selected outcomes (particularly those related to response to standard care (e.g., effectiveness, side effects)) that would justify the conduct of larger, randomized-controlled trials.

  • In randomized-controlled trials, provide sufficient detail of the KD and control diets (ensuring that they are comparable on vitamins, mineral and other nutrients) so they could be replicated by other investigators.

  • Develop a standardized method to monitor and quantify adherence and tolerance to the KD.

  • Develop a set of standardized assessments and outcome measures that include the full array of relevant variables (e.g., imaging of tumor characteristics, body composition, quality of life, and survival).

  • Distinguish trials based on whether they attempt to isolate the unique effects of KD versus those which seek to estimate its effects as an adjunctive therapy.

  • Examine the effects of exogenous ketones, alone and in conjunction with a KD, to determine whether they have synergistic or additive effects.

  • Because it is unlikely that KD will cure cancer, trials should focus on whether KD reduces cancer progression or recurrence in those who experience remission through standard care.

It’s worth asking - is progress is not being made in regard to curing cancer because they’re focusing on the wrong things?

Ultimately I believe the metabolic theory, much like the parasitic theory of cancer makes sense but probably does not explain every cancer, nor would it fix every cancer. The reason I say this is that I do not believe we are still dealing with cancer as a natural phenomenon. Cancer as a genetic issue certainly appears credible in many cases. I think many of these cancers stemming from genetic mutations will eventually be understood to have come from the poisons we are putting in our systems today; poisons that did not exist centuries ago.

The mRNA poisons are a great example. These gene therapy poisons and many other things we are putting in our body have a substantial impact on the genetic material and the functionality of our cells. Radiation can cause cellular mutation and every single radio signal and cellular tower in this country emit low levels of radiation and we have not properly studied their cancer causing potential. Modern life is full of things that may account for a major increase in cancer that is truly based on genetic mutation rather than a parasite or metabolic issue… or maybe these things contribute to metabolic issues in some way.

After researching and putting out these articles on cancer and causes I frankly am at the point I believe all three major theories of cancer seem credible. I am also appalled to see that only one of them is studied and that is the theory that makes the money. If we want to understand cancer we need to start by getting money out of the picture. Cancer kills and should not be political and should not be about money - but it is. I think it may be time we do something about that… more to come.

If you’d like to hear more on cancer as a metabolic disease the FLCCC Alliance published a webinar with Dr. Paul Marik and Dr. Thomas Seyfried that you can watch here.

“Billions spent on novel gene-targeting cancer drugs provide a chance to live only 2.4-months longer!”

Dr. Thomas Seyfried

Sources:

  1. Clinical Trial Evidence Supporting US Food and Drug Administration Approval of Novel Cancer Therapies Between 2000 and 2016 - PubMed (nih.gov)

  2. Cancer as a Metabolic Disease: On the Origin, Management, and Prevention of Cancer: 9780470584927: Medicine & Health Science Books 

  3. Cancer: An Unbiased Overview in Preparation for Our Upcoming War on Cancer (substack.com)

  4. Mitochondria - Definition, Function & Structure | Biology Dictionary

  5. Home - Thomas Seyfried (tomseyfried.com)

  6. Cancer as A Metabolic Disease - FLCCC Alliance (covid19criticalcare.com)

  7. Hypoxia regulates the mitochondrial activity of hepatocellular carcinoma cells through HIF/HEY1/PINK1 pathway | Cell Death & Disease (nature.com)

  8. HIF-1α-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation | Signal Transduction and Targeted Therapy (nature.com)

  9. Press-pulse: a novel therapeutic strategy for the metabolic management of cancer | Nutrition & Metabolism | Full Text (biomedcentral.com)

  10. Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy - PMC (nih.gov)

  11. Ketogenic Diet in Cancer Prevention and Therapy: Molecular Targets and Therapeutic Opportunities - PMC (nih.gov)

  12. chemotherapy-spreading-cancer-pdf.pdf (mercola.com)

  13. Johns Hopkins Medicine Celebrates Its Contributions to Keto Therapy as Diet Turns 100 | Johns Hopkins Medicine

  14. Gleevec: Uses, Dosage, Side Effects - Drugs.com

  15. Ketogenic Diet for Cancer: Critical Assessment and Research Recommendations - PMC (nih.gov)

  16. Herceptin (Trastuzumab): Side Effects, How it Works, and More (breastcancer.org)

     
     
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